Biomarkers of neuronal damage in saturation diving-a controlled observational study.

ABSTRACT:

Purpose

A prospective and controlled observational study was performed to determine if the central nervous system injury markers glial fibrillary acidic protein (GFAp), neurofilament light (NfL) and tau concentrations changed in response to a saturation dive.

Methods

The intervention group consisted of 14 submariners compressed to 401 kPa in a dry hyperbaric chamber. They remained pressurized for 36 h and were then decompressed over 70 h. A control group of 12 individuals was used. Blood samples were obtained from both groups before, during and after hyperbaric exposure, and from the intervention group after a further 25-26 h.

Results

There were no statistically significant changes in the concentrations of GFAp, NfL and tau in the intervention group. During hyperbaric

SUBMITTER: Rosen A 

PROVIDER: S-EPMC7674315 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature