Modulation of Cancer-Associated Fibrotic Stroma by An Integrin α_vβ₃ Targeting Protein for Pancreatic Cancer Treatment.

ABSTRACT:

Background & aims

Pancreatic ductal adenocarcinoma (PDAC) is resistant to most therapeutics owing to dense fibrotic stroma orchestrated by cancer-associated pancreatic stellate cells (CAPaSC). CAPaSC also support cancer cell growth, metastasis, and resistance to apoptosis. Currently, there is no effective therapy for PDAC that specifically targets CAPaSC. We previously reported a rationally designed protein, ProAgio, that targets integrin α_vβ₃ at a novel site and induces apoptosis in integrin α_vβ₃-expressing cells. Because both CAPaSC and angiogenic endothelial cells express high levels of integrin α_vβ₃, we aimed to analyze the effects of ProAgio in PDAC tumor.

Methods

Expression of integrin α_vβ

SUBMITTER: Turaga RC 

PROVIDER: S-EPMC7674520 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature