Gene Expression Signatures Identify Biologically Homogenous Subgroups of Grade 2 Meningiomas.

ABSTRACT:

Introduction

Meningiomas are the most common brain tumor, with prevalence of approximately 3%. Histological grading has a major role in determining treatment choice and predicting outcome. While indolent grade 1 and aggressive grade 3 meningiomas exhibit relatively homogeneous clinical behavior, grade 2 meningiomas are far more heterogeneous, making outcome prediction challenging. We hypothesized two subgroups of grade 2 meningiomas which biologically resemble either World Health Organization (WHO) grade 1 or WHO grade 3. Our aim was to establish gene expression signatures that separate grade 2 meningiomas into two homogeneous subgroups: a more indolent subtype genetically resembling grade 1 and a more aggressive subtype resembling grade 3.

Methods

We carried out an observat

SUBMITTER: Zador Z 

PROVIDER: S-EPMC7674612 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature