Structure-function relationship of the posterior subthalamic area with directional deep brain stimulation for essential tremor.

ABSTRACT: Deep Brain Stimulation of the posterior subthalamic area is an emergent target for the treatment of Essential Tremor. Due to the heterogeneous and complex anatomy of the posterior subthalamic area, it remains unclear which specific structures mediate tremor suppression and different side effects. The objective of the current work was to yield a better understanding of what anatomical structures mediate the different clinical effects observed during directional deep brain stimulation of that area. We analysed a consecutive series of 12 essential tremor patients. Imaging analysis and systematic clinical testing performed 4-6 months postoperatively yielded location, clinical efficacy and corresponding therapeutic windows for 160 directional contacts. Overlap ratios between individual activati

SUBMITTER: Levy JP 

PROVIDER: S-EPMC7674616 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature