Imbalance between genomic gain and loss identifies high-risk neuroblastoma patients with worse outcomes.

ABSTRACT: Survival in high-risk neuroblastoma (HR-NB) patients remains poor despite multimodal treatment. We aimed to identify HR-NB patients with worse outcomes by analyzing the genomic instability derived from segmental chromosomal aberrations. We calculated 3 genomic instability indexes for primary tumor SNP array profiles from 127 HR-NB patients: (1) Copy number aberration burden (%gains_length+%losses_length), (2) copy number load (CNL) (%gains_length-%losses_length) and (3) net genomic load (NGL) (%gains_amount-%losses_amount). Tumors were classified according to positive or negative CNL and NGL genomic subtypes. The impact of the genomic instability indexes on overall survival (OS) was assessed with Cox regression. We identified 38%

SUBMITTER: Fernandez-Blanco B 

PROVIDER: S-EPMC7674617 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature