A large-scale genome-wide association study meta-analysis of cannabis use disorder.
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ABSTRACT:
SUBMITTER: Johnson EC
PROVIDER: S-EPMC7674631 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
A large-scale genome-wide association study meta-analysis of cannabis use disorder.
Johnson Emma C EC Demontis Ditte D Thorgeirsson Thorgeir E TE Walters Raymond K RK Polimanti Renato R Hatoum Alexander S AS Sanchez-Roige Sandra S Paul Sarah E SE Wendt Frank R FR Clarke Toni-Kim TK Lai Dongbing D Reginsson Gunnar W GW Zhou Hang H He June J Baranger David A A DAA Gudbjartsson Daniel F DF Wedow Robbee R Adkins Daniel E DE Adkins Amy E AE Alexander Jeffry J Bacanu Silviu-Alin SA Bigdeli Tim B TB Boden Joseph J Brown Sandra A SA Bucholz Kathleen K KK Bybjerg-Grauholm Jonas J Corley Robin P RP Degenhardt Louisa L Dick Danielle M DM Domingue Benjamin W BW Fox Louis L Goate Alison M AM Gordon Scott D SD Hack Laura M LM Hancock Dana B DB Hartz Sarah M SM Hickie Ian B IB Hougaard David M DM Krauter Kenneth K Lind Penelope A PA McClintick Jeanette N JN McQueen Matthew B MB Meyers Jacquelyn L JL Montgomery Grant W GW Mors Ole O Mortensen Preben B PB Nordentoft Merete M Pearson John F JF Peterson Roseann E RE Reynolds Maureen D MD Rice John P JP Runarsdottir Valgerdur V Saccone Nancy L NL Sherva Richard R Silberg Judy L JL Tarter Ralph E RE Tyrfingsson Thorarinn T Wall Tamara L TL Webb Bradley T BT Werge Thomas T Wetherill Leah L Wright Margaret J MJ Zellers Stephanie S Adams Mark J MJ Bierut Laura J LJ Boardman Jason D JD Copeland William E WE Farrer Lindsay A LA Foroud Tatiana M TM Gillespie Nathan A NA Grucza Richard A RA Harris Kathleen Mullan KM Heath Andrew C AC Hesselbrock Victor V Hewitt John K JK Hopfer Christian J CJ Horwood John J Iacono William G WG Johnson Eric O EO Kendler Kenneth S KS Kennedy Martin A MA Kranzler Henry R HR Madden Pamela A F PAF Maes Hermine H HH Maher Brion S BS Martin Nicholas G NG McGue Matthew M McIntosh Andrew M AM Medland Sarah E SE Nelson Elliot C EC Porjesz Bernice B Riley Brien P BP Stallings Michael C MC Vanyukov Michael M MM Vrieze Scott S Davis Lea K LK Bogdan Ryan R Gelernter Joel J Edenberg Howard J HJ Stefansson Kari K Børglum Anders D AD Agrawal Arpana A
The lancet. Psychiatry 20201020 12
<h4>Background</h4>Variation in liability to cannabis use disorder has a strong genetic component (estimated twin and family heritability about 50-70%) and is associated with negative outcomes, including increased risk of psychopathology. The aim of the study was to conduct a large genome-wide association study (GWAS) to identify novel genetic variants associated with cannabis use disorder.<h4>Methods</h4>To conduct this GWAS meta-analysis of cannabis use disorder and identify associations with ...[more]
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