Stochastic Gain and Loss of Novel Transcribed Open Reading Frames in the Human Lineage.

ABSTRACT: In addition to known genes, much of the human genome is transcribed into RNA. Chance formation of novel open reading frames (ORFs) can lead to the translation of myriad new proteins. Some of these ORFs may yield advantageous adaptive de novo proteins. However, widespread translation of noncoding DNA can also produce hazardous protein molecules, which can misfold and/or form toxic aggregates. The dynamics of how de novo proteins emerge from potentially toxic raw materials and what influences their long-term survival are unknown. Here, using transcriptomic data from human and five other primates, we generate a set of transcribed human ORFs at six conservation levels to investigate which properties influence the early emergence and long-term retention of these expressed ORFs. As these taxa di

SUBMITTER: Dowling D 

PROVIDER: S-EPMC7674706 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature