Inhomogeneities in 3D Collagen Matrices Impact Matrix Mechanics and Cancer Cell Migration.

ABSTRACT: Cell motility under physiological and pathological conditions including malignant progression of cancer and subsequent metastasis are founded on environmental confinements. During the last two decades, three-dimensional cell migration has been studied mostly by utilizing biomimetic extracellular matrix models. In the majority of these studies, the in vitro collagen scaffolds are usually assumed to be homogenous, as they consist commonly of one specific type of collagen, such as collagen type I, isolated from one species. These collagen matrices should resemble in vivo extracellular matrix scaffolds physiologically, however, mechanical phenotype and functional reliability have been addressed poorly due to certain limitations based on the assumption of homogeneity. How local va

SUBMITTER: Hayn A 

PROVIDER: S-EPMC7674772 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature