Transcriptome-Wide m⁶A Methylation in Skin Lesions From Patients With Psoriasis Vulgaris.

ABSTRACT: N⁶-methyladenosine (m⁶A) methylation, as the most prevalent internal RNA modification, has been revealed to play critical roles in various biological functions. In this study, we performed m⁶A transcriptome-wide profiling in three kinds of skin tissue: involved psoriatic skin (PP), uninvolved psoriatic skin (PN), and healthy control skin samples (NN). The findings revealed that transcripts of PP contained the fewest m⁶A peaks and lowest m⁶A peak density. The greatest differences of m⁶A methylation were observed in the PP vs. NN and PP vs. PN comparisons. Intriguingly, in these comparisons, hypermethylated m⁶A was mainly enriched within the CDSs and 3'UTRs, while hypomethylated m⁶A was not only enriched

SUBMITTER: Wang YN 

PROVIDER: S-EPMC7674922 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature