Harnessing the Neural Stem Cell Secretome for Regenerative Neuroimmunology.

ABSTRACT: Increasing evidence foresees the secretome of neural stem cells (NSCs) to confer superimposable beneficial properties as exogenous NSC transplants in experimental treatments of traumas and diseases of the central nervous system (CNS). Naturally produced secretome biologics include membrane-free signaling molecules and extracellular membrane vesicles (EVs) capable of regulating broad functional responses. The development of high-throughput screening pipelines for the identification and validation of NSC secretome targets is still in early development. Encouraging results from pre-clinical animal models of disease have highlighted secretome-based (acellular) therapeutics as providing significant improvements in biochemical and behavioral measurements. Most of thes

SUBMITTER: Willis CM 

PROVIDER: S-EPMC7674923 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature