A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos.

ABSTRACT: Variation in levels of the human metabolome reflect changes in homeostasis, providing a window into health and disease. The genetic impact on circulating metabolites in Hispanics, a population with high cardiometabolic disease burden, is largely unknown. We conducted genome-wide association analyses on 640 circulating metabolites in 3,926 Hispanic Community Health Study/Study of Latinos participants. The estimated heritability for 640 metabolites ranged between 0%-54% with a median at 2.5%. We discovered 46 variant-metabolite pairs (p value < 1.2 × 10^-10, minor allele frequency ≥ 1%, proportion of variance explained [PEV] mean = 3.4%, PEV_range = 1%-22%) with generalized effects in two population-based studies and confirmed 301 known locus-metabolite associations. Half

SUBMITTER: Feofanova EV 

PROVIDER: S-EPMC7675000 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature