Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk.

ABSTRACT: Previous research has shown that polygenic risk scores (PRSs) can be used to stratify women according to their risk of developing primary invasive breast cancer. This study aimed to evaluate the association between a recently validated PRS of 313 germline variants (PRS₃₁₃) and contralateral breast cancer (CBC) risk. We included 56,068 women of European ancestry diagnosed with first invasive breast cancer from 1990 onward with follow-up from the Breast Cancer Association Consortium. Metachronous CBC risk (N = 1,027) according to the distribution of PRS₃₁₃ was quantified using Cox regression analyses. We assessed PRS₃₁₃ interaction with age at first diagnosis, family history, morphology, ER status, PR status, and HER2 status, and (neo)adjuvant therapy. In stu

SUBMITTER: Kramer I 

PROVIDER: S-EPMC7675034 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature