Biomass-Derived Multilayer-Structured Microparticles for Accelerated Hemostasis and Bone Repair.

ABSTRACT: It is very desirable to develop advanced sustainable biomedical materials with superior biosafety and bioactivity for clinical applications. Herein, biomass-derived multilayer-structured absorbable microparticles (MQ _x T _y ) composed of starches and plant polyphenols are readily constructed for the safe and effective treatment of bone defects with intractable bleeding by coating multiple layers of quaternized starch (Q⁺) and tannic acid onto microporous starch microparticles via facile layer-by-layer assembly. MQ _x T _y microparticles exhibit efficient degradability, low cytotoxicity, and good blood compatibility. Among various MQ _x T _y microparticles with distinct Q^+<

SUBMITTER: Liu JY 

PROVIDER: S-EPMC7675182 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature