Antidiabetic Effects of a Tripeptide That Decreases Abundance of Na⁺-d-glucose Cotransporter SGLT1 in the Brush-Border Membrane of the Small Intestine.

ABSTRACT: In enterocytes, protein RS1 (RSC1A1) mediates an increase of glucose absorption after ingestion of glucose-rich food via upregulation of Na⁺-d-glucose cotransporter SGLT1 in the brush-border membrane (BBM). Whereas RS1 decelerates the exocytotic pathway of vesicles containing SGLT1 at low glucose levels between meals, RS1-mediated deceleration is relieved after ingestion of glucose-rich food. Regulation of SGLT1 is mediated by RS1 domain RS1-Reg, in which Gln-Ser-Pro (QSP) is effective. In contrast to QSP and RS1-Reg, Gln-Glu-Pro (QEP) and RS1-Reg with a serine to glutamate exchange in the QSP motif downregulate the abundance of SGLT1 in the BBM at high intracellular glucose concentrations by about 50%. We investigated whether oral application of QEP improves diabe

SUBMITTER: Otto C 

PROVIDER: S-EPMC7675577 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature