Gigantol Targets MYC for Ubiquitin-proteasomal Degradation and Suppresses Lung Cancer Cell Growth.

ABSTRACT:

Background

Gigantol is a pharmacologically active bibenzyl compound exerting potential anticancer activities. At non-toxic concentrations, it reduces cancer stem cell properties and tumorigenicity. The mechanisms of the effects of gigantol on cancer cell growth are largely unknown. This study aimed to unravel the molecular profile and identify the prominent molecular mechanism of the effects of gigantol in controlling lung cancer cell proliferation.

Materials and methods

Proteomics and bioinformatics analysis were used accompanied by experimental molecular pharmacology approaches.

Results

Gigantol exhibited antiproliferative effects on human lung cancer cells confirmed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide proliferation assay and colony gro

SUBMITTER: Losuwannarak N 

PROVIDER: S-EPMC7675646 | biostudies-literature | 2020 Nov-Dec

REPOSITORIES: biostudies-literature