The association of miR-27a rs895819 polymorphism with colorectal cancer risk in Chinese population.

ABSTRACT:

Background

Besides environment and living habits, such as a sedentary lifestyle, smoking and drinking, genetic variation also plays an important role in the development of colorectal cancer (CRC). This study was aimed to investigate the role of miR-27a rs895819 polymorphism on CRC risk in Chinese population.

Methods

In a case-control study including 208 CRC and 312 age- and gender-matched healthy control subjects, the rs895819 polymorphism was genotyped using the TaqMan allelic discrimination assay. Furthermore, a pooled analysis based on eligible studies was performed by using the STATA software.

Results

Logistic regression analysis showed that the rs895819 polymorphism was not associated with CRC risk. However, a pooled analysis based on five studies from Chinese po

SUBMITTER: Zhang S 

PROVIDER: S-EPMC7676186 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature