CASR rs1801725 polymorphism is associated with the risk and prognosis of colorectal cancer: A case-control study.

ABSTRACT:

Background

The extracellular calcium-sensing receptor (CASR) controls body calcium homeostasis. Increased levels of calcium are associated with protecting against colorectal cancer (CRC). This study aimed to determine the relationship between CASR gene rs1801725 polymorphism and CRC risk and prognosis.

Methods

We conducted a hospital-based case-control study and a meta-analysis to evaluate the association of CASR gene rs1801725 polymorphism with CRC susceptibility.

Results

This study proved that CASR rs1801725 polymorphism was associated with a higher risk to develop CRC (TT vs GG: OR 1.92, 95% CI [1.03-3.59], P = .042; T vs G: OR 1.30, 95% CI [1.03-1.64], P = .030). Subgroup analysis showed that this polymorphism increased the risk of CRC among smokers, and those age

SUBMITTER: Diao YE 

PROVIDER: S-EPMC7676189 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature