17α-ethynylestradiol prevents the natural male-to-female sex change in gilthead seabream (Sparus aurata L.).

ABSTRACT: Exposure to 17α-ethynylestradiol (EE₂, 5 μg/g food) impairs some reproductive events in the protandrous gilthead seabream and a short recovery period does not allow full recovery. In this study, spermiating seabream males in the second reproductive cycle (RC) were fed a diet containing 5 or 2.5 μg EE₂/g food for 28 days and then a commercial diet without EE₂ for the remaining RC. Individuals were sampled at the end of the EE₂ treatment and then at the end of the RC and at the beginning of the third RC, 146 and 333 days after the cessation of treatment, respectively. Increased hepatic transcript levels of the gene coding for vitellogenin (vtg) and plasma levels of Vtg indicated both concentrations of EE₂ caused endocrine disruption. Mod

SUBMITTER: Garcia Hernandez MP 

PROVIDER: S-EPMC7676269 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature