PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis.

ABSTRACT: The sensation of pain is essential for the preservation of the functional integrity of the body. However, the key molecular regulators necessary for the initiation of the development of pain-sensing neurons have remained largely unknown. Here, we report that, in mice, inactivation of the transcriptional regulator PRDM12, which is essential for pain perception in humans, results in a complete absence of the nociceptive lineage, while proprioceptive and touch-sensitive neurons remain. Mechanistically, our data reveal that PRDM12 is required for initiation of neurogenesis and activation of a cascade of downstream pro-neuronal transcription factors, including NEUROD1, BRN3A, and ISL1, in the nociceptive lineage while it represses alternative fates other than nociceptors in progenitor cells. Ou

SUBMITTER: Bartesaghi L 

PROVIDER: S-EPMC7676307 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature