The G-protein Coupled Receptor GPR8 Regulates Secondary Metabolism in Trichoderma reesei.

ABSTRACT: Changing environmental conditions are of utmost importance for regulation of secondary metabolism in fungi. Different environmental cues including the carbon source, light and the presence of a mating partner can lead to altered production of compounds. Thereby, the heterotrimeric G-protein pathway is of major importance for sensing and adjustment of gene regulation. Regulation of secondary metabolism is crucial in the biotechnological workhorse Trichoderma reesei for knowledge-based adjustment in industrial fermentations, but also with respect to the potential use as a host for heterologous compound production. We investigated the function of the class VII G-protein coupled receptor (GPCR) gene gpr8 that is localized in the vicinity of the SOR cluster, which is responsible f

SUBMITTER: Hinterdobler W 

PROVIDER: S-EPMC7676458 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature