Bacterial "Virulence" Traits and Host Demographics Predict Escherichia coli Colonization Behaviors Within Households.

ABSTRACT:

Background

Although intestinal colonization precedes most extraintestinal Escherichia coli infections, colonization-promoting factors are incompletely understood. We compared within-household E. coli colonization patterns with host and bacterial traits.

Methods

Twenty-two veterans with a clinical E. coli isolate and their 46 human and animal household members underwent longitudinal fecal sampling. Distinct E. coli strains were characterized for phylogenetic background, virulence genes, antibiotic resistance, and colonization behaviors. Host and bacterial traits were assessed statistically as predictors of colonization behaviors.

Results

Among the 139 unique-by-household fecal E. coli strains, univariable predictors of colonization be

SUBMITTER: Fox TC 

PROVIDER: S-EPMC7676507 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature