Antibody profiling and prevalence in US patients during the SARS-CoV2 pandemic.

ABSTRACT:

Background

Antibody diagnostics play an important role in disease detection and can potentially aid in monitoring of the immune responses to see if an individual has developed immunity. Developing high throughput diagnostics which does not involve handling of infectious material becomes imperative in the case of pandemics such as the recent outbreak of SARS-CoV2.

Methods

A protein microarray technology was used to detect the plurality of antibody response to four novel antigens namely S1 glycoprotein, Receptor binding domain (RBD), S2 glycoprotein and Nucleoprotein of the novel coronavirus named SARS-CoV2 using serum samples. A DBS card was additionally used to compare its performance with a venipuncture-based serum separator tube (SST) draw.

Results

The three main su

SUBMITTER: Krishnamurthy HK 

PROVIDER: S-EPMC7676701 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature