Characterization of TMAO productivity from carnitine challenge facilitates personalized nutrition and microbiome signatures discovery.

ABSTRACT: The capability of gut microbiota in degrading foods and drugs administered orally can result in diversified efficacies and toxicity interpersonally and cause significant impact on human health. Production of atherogenic trimethylamine N-oxide (TMAO) from carnitine is a gut microbiota-directed pathway and varies widely among individuals. Here, we demonstrated a personalized TMAO formation and carnitine bioavailability from carnitine supplements by differentiating individual TMAO productivities with a recently developed oral carnitine challenge test (OCCT). By exploring gut microbiome in subjects characterized by TMAO producer phenotypes, we identified 39 operational taxonomy units that were highly correlated to TMAO productivity, including Emergencia timonensis, which has been recently disc

SUBMITTER: Wu WK 

PROVIDER: S-EPMC7676756 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature