Transferrin Receptor Functionally Marks Thermogenic Adipocytes.

ABSTRACT:

Background

Thermogenic adipocytes, including beige and brown adipocytes, are critical for thermogenesis and energy homeostasis. Identification of functional cell surface markers of thermogenic adipocytes is of significance for potential application in biological and clinical practices.

Methods

With a combination of RNA-sequencing of in vivo and in vitro models, we identified transferrin receptor (Tfr1), a receptor specialized for cellular iron uptake, as a previously unappreciated cell surface molecule for thermogenic adipocytes compared to white adipocytes. The alternation of Tfr1 levels under physiological and pathological stimuli was assessed, and the mitochondria functionality, browning capacity, and iron metabolism of mature adipocytes were examined with <

SUBMITTER: Qiu J 

PROVIDER: S-EPMC7676909 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature