How Ancestry Influences the Chances of Finding Unrelated Donors: An Investigation in Admixed Brazilians.

ABSTRACT: A match of HLA loci between patients and donors is critical for successful hematopoietic stem cell transplantation. However, the extreme polymorphism of HLA loci - an outcome of millions of years of natural selection - reduces the chances that two individuals will carry identical combinations of multilocus HLA genotypes. Further, HLA variability is not homogeneously distributed throughout the world: African populations on average have greater variability than non-Africans, reducing the chances that two unrelated African individuals are HLA identical. Here, we explore how self-identification (often equated with "ethnicity" or "race") and genetic ancestry are related to the chances of finding HLA compatible donors in a large sample from Brazil, a highly admixed country. We query REDOME, Braz

SUBMITTER: Nunes K 

PROVIDER: S-EPMC7677137 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature