Hydrogels for 3D Neural Tissue Models: Understanding Cell-Material Interactions at a Molecular Level.

ABSTRACT: The development of 3D neural tissue analogs is of great interest to a range of biomedical engineering applications including tissue engineering of neural interfaces, treatment of neurodegenerative diseases and in vitro assessment of cell-material interactions. Despite continued efforts to develop synthetic or biosynthetic hydrogels which promote the development of complex neural networks in 3D, successful long-term 3D approaches have been restricted to the use of biologically derived constructs. In this study a poly (vinyl alcohol) biosynthetic hydrogel functionalized with gelatin and sericin (PVA-SG), was used to understand the interplay between cell-cell communication and cell-material interaction. This was used to probe critical short-term interactions that determine the success

SUBMITTER: Vallejo-Giraldo C 

PROVIDER: S-EPMC7677185 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature