Transcapillary PO₂ gradients in contracting muscles across the fibre type and oxidative continuum.

ABSTRACT:

Key points

Within skeletal muscle the greatest resistance to oxygen transport is thought to reside across the short distance at the red blood cell-myocyte interface. These structures generate a significant transmural oxygen pressure (PO₂ ) gradient in mixed fibre-type muscle. Increasing O₂ flux across the capillary wall during exercise depends on: (i) the transmural O₂ pressure gradient, which is maintained in mixed-fibre muscle, and/or (ii) elevating diffusing properties between microvascular and interstitial compartments resulting, in part, from microvascular haemodynamics and red blood cell distribution. We evaluated the PO₂ within the microvascular and interstitial spaces of muscles spanning the slow- to fast-twitch fibre and high- to

SUBMITTER: Colburn TD 

PROVIDER: S-EPMC7677211 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature