Ontology highlight
ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC7677223 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Wang Wei W Zheng Qingbing Q Pan Dequan D Yu Hai H Fu Wenkun W Liu Jian J He Maozhou M Zhu Rui R Cai Yuze Y Huang Yang Y Zha Zhenghui Z Chen Zhenqin Z Ye Xiangzhong X Han Jinle J Que Yuqiong Y Wu Ting T Zhang Jun J Li Shaowei S Zhu Hua H Zhou Z Hong ZH Cheng Tong T Xia Ningshao N
Nature microbiology 20200907 12
Varicella-zoster virus (VZV) is a medically important human herpesvirus that causes chickenpox and shingles, but its cell-associated nature has hindered structure studies. Here we report the cryo-electron microscopy structures of purified VZV A-capsid and C-capsid, as well as of the DNA-containing capsid inside the virion. Atomic models derived from these structures show that, despite enclosing a genome that is substantially smaller than those of other human herpesviruses, VZV has a similarly si ...[more]