Bovine Interferon Lambda Is a Potent Antiviral Against SARS-CoV-2 Infection in vitro.

ABSTRACT: Interferon lambda (IFN-λ) is an antiviral naturally produced in response to viral infections, with activity on cells of epithelial origin and located in the mucosal surfaces. This localized activity results in reduced toxicity compared to type I IFNs, whose receptors are ubiquitously expressed. IFN-λ has been effective in the therapy of respiratory viral infections, playing a crucial role in potentiating adaptive immune responses that initiate at mucosal surfaces. Human IFN-λ has polymorphisms that may cause differences in the interaction with the specific receptor in the human population. Interestingly, bovine IFN-λ3 has an in silico-predicted higher affinity for the human receptor than its human counterparts, with high identity with different human IFN-λ variants, making it a suit

SUBMITTER: Cardoso NP 

PROVIDER: S-EPMC7677234 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature