Ocular Physiologically Based Pharmacokinetic Modeling for Ointment Formulations.

ABSTRACT:

Purpose

The purpose of this study is to show how the Ocular Compartmental Absorption & Transit (OCAT™) model in GastroPlus^® can be used to characterize ocular drug pharmacokinetic performance in rabbits for ointment formulations.

Methods

A newly OCAT™ model developed for fluorometholone, as well as a previously verified model for dexamethasone, were used to characterize the aqueous humor (AH) concentration following the administration of multiple ointment formulations to rabbit. The model uses the following parameters: application surface area (SA), a fitted application time, and the fitted Higuchi release constant to characterize the rate of passage of the active pharmaceutical ingredient from the ointment formulations into the tears in vivo.

Results

Param

SUBMITTER: Le Merdy M 

PROVIDER: S-EPMC7677276 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature