IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A⁺Foxp3⁺ Cells During Mucosal Infection and Is Dysregulated With Aging.

ABSTRACT: CD4⁺Foxp3⁺T_regs maintain immune homeostasis, but distinct mechanisms underlying their functional heterogeneity during infections are driven by specific cytokine milieu. Here we show that MyD88 deletion in Foxp3⁺ cells altered their function and resulted in increased fungal burden and immunopathology during oral Candida albicans (CA) challenge. Excessive inflammation due to the absence of MyD88 in T_regs coincided with a reduction of the unique population of IL-17A expressing Foxp3⁺ cells (T_reg17) and an increase in dysfunctional IFN-γ⁺/Foxp3⁺ cells (T_regIFN-γ) in infected mice. Failure of MyD88^-/- T_regs to regulate effector CD4⁺ T cell functio

SUBMITTER: Bhaskaran N 

PROVIDER: S-EPMC7677307 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature