Title NMR-based metabolic profiling provides diagnostic and prognostic information in critically ill children with suspected infection.

ABSTRACT: Sepsis, defined as life-threatening organ dysfunction caused by infection is difficult to distinguish clinically from infection or post-operative inflammation. We hypothesized that in a heterogeneous group of critically ill children, there would be different metabolic profiles between post-operative inflammation, bacterial and viral infection and infection with or without organ dysfunction. 1D ¹H nuclear magnetic resonance spectra were acquired in plasma samples from critically ill children. We included children with bacterial (n = 25) and viral infection (n = 30) and controls (n = 58) (elective cardiac surgery without infection). Principal component analysis was used for data exploration and partial least squares discriminant analysis models for the differences between groups.

SUBMITTER: Grauslys A 

PROVIDER: S-EPMC7677384 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature