Changes in Resting and Exercise Hemodynamics Early After Heart Transplantation: A Simulation Perspective.

ABSTRACT: Introduction: During heart transplantation (HTx), cardiac denervation is inevitable, thus typically resulting in chronic resting tachycardia and chronotropic incompetence with possible consequences in patient quality of life and clinical outcomes. To this date, knowledge of hemodynamic changes early after HTx is still incomplete. This study aims at providing a model-based description of the complex hemodynamic changes at rest and during exercise in HTx recipients (HTxRs). Materials and Methods: A numerical model of early HTxRs is developed that integrates intrinsic and autonomic heart rate (HR) control into a lumped-parameter cardiovascular system model. Intrinsic HR control is realized by a single-cell sinoatrial (SA) node model. Autonomic HR control is governed by aortic ba

SUBMITTER: Haberbusch M 

PROVIDER: S-EPMC7677526 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature