Dopamine receptor D1- and D2-agonists do not spark brown adipose tissue thermogenesis in mice.

ABSTRACT: Brown adipose tissue (BAT) thermogenesis is considered a potential target for treatment of obesity and diabetes. In vitro data suggest dopamine receptor signaling as a promising approach; however, the biological relevance of dopamine receptors in the direct activation of BAT thermogenesis in vivo remains unclear. We investigated BAT thermogenesis in vivo in mice using peripheral administration of D1-agonist SKF38393 or D2-agonist Sumanirole, infrared thermography, and in-depth molecular analyses of potential target tissues; and ex vivo in BAT explants to identify direct effects on key thermogenic markers. Acute in vivo treatment with the D1- or D2-agonist caused a short spike or brief decrease in BAT temperature, respectively. However, repeated daily administration did not induce lasting e

SUBMITTER: Raffaelli FM 

PROVIDER: S-EPMC7677542 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature