Evolutionary and Structural Studies of NCoV and SARS CoV-Spike proteins and their association with ACE2 Receptor

ABSTRACT: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)/Novel Corona Virus Disease-19 (nCOVID-19)/COVID-19 has only been discovered recently, and so our understanding of the disease epidemiology is continuously evolving. WHO has declared it a worldwide pandemic with high morbidity and significant mortality, hence it has been announced as the global health and wealth emergency. At present there is no any specific therapy available to fight against this virus, hence the drug repositioning is the most challenging to entire scientific community. The aim of this study is to determine the mutation(s) in the sequence of the spike protein, which plays a significant role in transmission from human to human. By using bioinformatics approach first we analyzed spike protein sequence of four neare

SUBMITTER: Kumar A 

PROVIDER: S-EPMC7677609 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature