The use of tumour markers in oesophageal cancer to quantify setup errors and baseline shifts during treatment.

ABSTRACT:

Purpose

To prospectively evaluate the feasibility of solid gold marker placement in oesophageal cancer patients and to quantify inter-fractional and intra-fractional (baseline shift) marker motion during radiation treatment. Radiotherapy target margins and matching strategies were investigated.

Materials/methods

Thirty-four markers were implanted by echo-endoscopy in 10 patients. Patients received a planning 4D CT, daily pre-treatment cone-beam CT (CBCT) and a post-treatment CBCT for at least five fractions. For fractions with both pre- and post-treatment CBCT, marker displacement between planning CT and pre-treatment CBCT (inter-fractional) and between pre-treatment and post-treatment CBCT (intra-fractional; only for fractions without rotational treatment couch correction)

SUBMITTER: Thomas M 

PROVIDER: S-EPMC7677672 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature