Perinatal inflammation alters histone 3 and histone 4 methylation patterns: Effects of MiR-29b supplementation.

ABSTRACT: Preterm birth is still a major health problem and maternal inflammation has been shown to play a role. The combination of maternal inflammation and neonatal hyperoxia contributes to epigenetic changes that influence gene expression and the development of bronchopulmonary dysplasia (BPD). We have previously demonstrated suppression of miR-29b and increases in DNA methylation in infants with severe BPD and in our mouse model of maternal inflammation and neonatal hyperoxia exposure. The present studies further explored epigenetic changes in the murine model to include histone methylation. We identified a global suppression of histone methylation in exposed mice and validated decreases in expression in well-defined histone modifications, specifically H3K4me3, H3K27me3, H3K36me2, H3K79me2, and

SUBMITTER: Sugar SS 

PROVIDER: S-EPMC7677713 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature