Machine Learning-Guided Adjuvant Treatment of Head and Neck Cancer.

ABSTRACT:

Importance

Postoperative chemoradiation is the standard of care for cancers with positive margins or extracapsular extension, but the benefit of chemotherapy is unclear for patients with other intermediate risk features.

Objective

To evaluate whether machine learning models could identify patients with intermediate-risk head and neck squamous cell carcinoma who would benefit from chemoradiation.

Design, setting, and participants

This cohort study included patients diagnosed with squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx from January 1, 2004, through December 31, 2016. Patients had resected disease and underwent adjuvant radiotherapy. Analysis was performed from October 1, 2019, through September 1, 2020. Patients were selected from

SUBMITTER: Howard FM 

PROVIDER: S-EPMC7677764 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature