ADAM22/LGI1 complex as a new actionable target for breast cancer brain metastasis.

ABSTRACT:

Background

Metastatic breast cancer is a major cause of cancer-related deaths in woman. Brain metastasis is a common and devastating site of relapse for several breast cancer molecular subtypes, including oestrogen receptor-positive disease, with life expectancy of less than a year. While efforts have been devoted to developing therapeutics for extra-cranial metastasis, drug penetration of blood-brain barrier (BBB) remains a major clinical challenge. Defining molecular alterations in breast cancer brain metastasis enables the identification of novel actionable targets.

Methods

Global transcriptomic analysis of matched primary and metastatic patient tumours (n = 35 patients, 70 tumour samples) identified a putative new actionable target for advanced breast cancer which was fu

SUBMITTER: Charmsaz S 

PROVIDER: S-EPMC7677775 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature