In vivo imaging of injured cortical axons reveals a rapid onset form of Wallerian degeneration.

ABSTRACT:

Background

Despite the widespread occurrence of axon and synaptic loss in the injured and diseased nervous system, the cellular and molecular mechanisms of these key degenerative processes remain incompletely understood. Wallerian degeneration (WD) is a tightly regulated form of axon loss after injury, which has been intensively studied in large myelinated fibre tracts of the spinal cord, optic nerve and peripheral nervous system (PNS). Fewer studies, however, have focused on WD in the complex neuronal circuits of the mammalian brain, and these were mainly based on conventional endpoint histological methods. Post-mortem analysis, however, cannot capture the exact sequence of events nor can it evaluate the influence of elaborated arborisation and synaptic architecture on the degener

SUBMITTER: Canty AJ 

PROVIDER: S-EPMC7677840 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature