Spatial heterogeneity of bacterial colonization across different gut segments following inter-species microbiota transplantation.

ABSTRACT:

Background

The microbiota presents a compartmentalized distribution across different gut segments. Hence, the exogenous microbiota from a particular gut segment might only invade its homologous gut location during microbiota transplantation. Feces as the excreted residue contain most of the large-intestinal microbes but lack small-intestinal microbes. We speculated that whole-intestinal microbiota transplantation (WIMT), comprising jejunal, ileal, cecal, and colonic microbiota, would be more effective for reshaping the entire intestinal microbiota than conventional fecal microbiota transplantation fecal microbiota transplantation (FMT).

Results

We modeled the compartmentalized colonization of the gut microbiota via transplanting the microbiota from jejunum, ileum, cecum, and

SUBMITTER: Li N 

PROVIDER: S-EPMC7677849 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature