Host genetic susceptibility to viral infections: the role of type I interferon induction.

ABSTRACT: The innate immune response is the major front line of defense against viral infections. It involves hundreds of genes with antiviral properties which expression is induced by type I interferons (IFNs) and are therefore called interferon stimulated genes (ISGs). Type I IFNs are produced after viral recognition by pathogen recognition receptors, which trigger a cascade of activation events. Human and mouse studies have shown that defective type I IFNs induction may hamper the ability to control viral infections. In humans, moderate to high-effect variants have been identified in individuals with particularly severe complications following viral infection. In mice, functional studies using knock-out alleles have revealed the specific role of most genes of the IFN pathway. Here, we review the

SUBMITTER: Bourdon M 

PROVIDER: S-EPMC7677911 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature