Polymorphisms in the airway epithelium related genes CDHR3 and EMSY are associated with asthma susceptibility.

ABSTRACT:

Background

As a main line of defense of the respiratory tract, the airway epithelium plays an important role in the pathogenesis of asthma. CDHR3 and EMSY were reported to be expressed in the human airway epithelium. Although previous genome-wide association studies found that the two genes were associated with asthma susceptibility, similar observations have not been made in the Chinese Han population.

Methods

A total of 300 asthma patients and 418 healthy controls unrelated Chinese Han individuals were enrolled. Tag-single nucleotide polymorphisms (Tag-SNPs) were genotyped and the associations between SNPs and asthma risk were analyzed by binary logistic regression analysis.

Results

After adjusting for confounding factors, the A allele of rs3847076 in CDHR3 was asso

SUBMITTER: Zhang M 

PROVIDER: S-EPMC7678090 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature