Functional genomics of AP-2α and AP-2γ in cancers: in silico study.

ABSTRACT:

Background

Among all causes of death, cancer is the most prevalent and is only outpaced by cardiovascular diseases. Molecular theory of carcinogenesis states that apoptosis and proliferation are regulated by groups of tumor suppressors or oncogenes. Transcription factors are example of proteins comprising representatives of both cancer-related groups. Exemplary family of transcription factors which exhibits dualism of function is Activating enhancer-binding Protein 2 (AP-2). Scientific reports concerning their function in carcinogenesis depend on particular family member and/or tumor type which proves the issue to be unsolved. Therefore, the present study examines role of the best-described AP-2 representatives, AP-2α and AP-2γ, through ontological analysis of their target genes an

SUBMITTER: Kolat D 

PROVIDER: S-EPMC7678100 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature