Genetic associations of in vivo pathology influence Alzheimer's disease susceptibility.

ABSTRACT:

Introduction

Although the heritability of sporadic Alzheimer's disease (AD) is estimated to be 60-80%, addressing the genetic contribution to AD risk still remains elusive. More specifically, it remains unclear whether genetic variants are able to affect neurodegenerative brain features that can be addressed by in vivo imaging techniques.

Methods

Targeted sequencing analysis of the coding and UTR regions of 132 AD susceptibility genes was performed. Neuroimaging data using ¹¹C-Pittsburgh Compound B positron emission tomography (PET), ¹⁸F-fluorodeoxyglucose PET, and MRI that are available from the KBASE (Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's disease) cohort were acquired. A total of 557 participants consisted of 336 c

SUBMITTER: Seo J 

PROVIDER: S-EPMC7678113 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature