Development and evaluation of mucoadhesive bigel containing tenofovir and maraviroc for HIV prophylaxis.

ABSTRACT:

Background

Sexual transmission of HIV is the most common means of acquiring the disease. Topical microbicides have been investigated to prevent transmission. This study will use a specific entry inhibitor, maraviroc, and a nucleotide reverse transcriptase inhibitor (NRTI), tenofovir, a dual combination which will provide a synergist effect that can enhance the efficacy of HIV microbicides via a mucoadhesive dual compartment bigel. Bigel formulation via hydrogel organogel linkages were developed and evaluated for their physicochemical characteristics, safety, and anti-HIV efficacy. In vitro diffusion studies were performed with Franz diffusion cells having effective diffusion surface area of 1.76cm² and receiver chamber volume of 15mL.

Result

The bigel formulations

SUBMITTER: Ilomuanya MO 

PROVIDER: S-EPMC7678373 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature