Associations of pituitary-ovarian hormones and white matter hyperintensities in recently menopausal women using hormone therapy.

ABSTRACT:

Objective

Little is known about how menopausal hormone treatment (HT) may influence the development of white matter hyperintensities (WMHs) in the brain. This study evaluated the associations of changes in levels of pituitary-ovarian hormones during HT and changes in WMH.

Methods

Women (n = 78 adherent to treatment) enrolled in the Kronos Early Estrogen Prevention Study underwent brain magnetic resonance imaging, and blood collection before and after 48 months of randomization to 0.45 mg/d oral conjugated equine estrogen (oCEE) daily, 50 μg/d transdermal 17β estradiol (tE2), or placebo pills and patches. Women in the active treatment groups also received oral 200 mg/d micronized progesterone the first 12 days of the month. Estradiol (E2), estrone (E1), follicle-stimulating h

SUBMITTER: Kling JM 

PROVIDER: S-EPMC7678409 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature