Increased copy number of syncytin-1 in the trophectoderm is associated with implantation of the blastocyst.

ABSTRACT:

Background

A key step in embryo implantation is the adhesion to and invasion of the endometrium by the blastocyst trophectoderm. The envelope proteins of HERV-W and -FRD (human endogenous retrovirus-W and -FRD), syncytin-1 and syncytin-2, are mainly distributed in the placenta, and play important roles in the development of the placenta. The placenta originates from the trophectoderm of the blastocyst. It is unclear whether the envelope proteins of HERV-W and -FRD have an effect on the development of the trophectoderm and whether they have any association with the implantation of the blastocyst.

Methods

The whole-genome amplification products of the human blastocyst trophectoderm were used to measure the copy number of syncytin-1 and syncytin-2 using real time qPCR. In addit

SUBMITTER: Guo L 

PROVIDER: S-EPMC7678462 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature