Oral Carriage of Streptococcus mutans Harboring the cnm Gene Relates to an Increased Incidence of Cerebral Microbleeds.

ABSTRACT:

Background and purpose

Cerebral microbleeds (CMB) are associated with stroke and cognitive impairment. We previously reported a high prevalence of CMB in people with Streptococcus mutans expressing Cnm, a collagen-binding protein in the oral cavity. S.mutans is a major pathogen responsible for dental caries. Repeated challenge with S.mutans harboring the cnm gene encoding Cnm induced cerebral bleeding in stroke-prone spontaneously hypertensive rats. The purpose of this longitudinal study is to examine the relationship of cnm-positive S.mutans to the development of CMB.

Methods

We retrospectively investigated patients with stroke receiving oral microbiological examination and head 3T magnetic resonance imaging eva

SUBMITTER: Hosoki S 

PROVIDER: S-EPMC7678651 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature