Gut Microbiome Modulates Response to Cancer Immunotherapy.

ABSTRACT: With the advent of next-generation sequencing approaches, there has been a renaissance in the microbiome field. Microbial taxonomy and function can now be characterized relatively easily and rapidly-no longer mandating complex culturing approaches. With this renaissance, there is now a strong and growing appreciation for the role of the microbiome (referring to microbes and their genomes) in modulating many facets of physiology-including overall immunity. This is particularly true of the gut microbiome, and there is now an evolving body of the literature demonstrating a role for gut microbes in modulating responses to cancer treatment-particularly immunotherapy. Gut microbes can modulate immunity and anti-tumor responses via a number of different interactions, and these will be discussed h

SUBMITTER: Khan MAW 

PROVIDER: S-EPMC7678709 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature